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Percutaneous vertebroplasty is safe and effective, and has a useful role in the treatment of painful vertebral compression fractures that do not respond to conventional treatments. Short-term complications, mainly the result of extravasation of cement, include increased pain and damage from heat or pressure to the spinal cord or nerve roots. Proper patient selection and good technique with adapted material is mandatory to minimize complications. Methyl methacrylate is too viscous to be handled without difficulty with normal syringe in the conventional way because injection time is short. With the conventional technique the glue was prepared than 3 to 4 two ml luer lock syringes were filled with the glue. The operator is left with little time and must handle with multiple syringes. To allow the injection with this technique the glue should be very fluid with higher risk of leak. Another disadvantage of this conventional technique is the manipulation of the glue, which increases the risk of infection. We describe a special screw-system syringe (Cemento® Optimed/Germany) that decreases the effort needed to aspirate and to inject the cement with increase of the injection time. In addition, it can standardize the injection pressures and control the injected volume because the screw applicator affords greater control of injection pressure and volume delivered than does the conventional method with reduction of complication particularly leak due to fluid glue.