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Over a period of 6 years, 186 periradicular injections were performed under CT-guidance. Short-term benefit of the PPRI is quite high with a good pain relief in 78% of extraforaminal herniations and 65% of the other localizations. The long-term result (persistence of relief for at least 6 months) was satisfactory only in PPRI of extraforaminal herniations : 68% good results two years after the infiltrations (average of 3 injections). Meningitis with neurologic damage ( quadriplegia, multiple cranial nerve palsies, nystagmus…) are described after epidural or intrathecal injection of steroids if strict sterility is not respected. A sterile technique will limit the risk of infection. With precise CT monitoring accidental intrathecal injection can be avoided. We had no complications in our series.