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Diaphragm is a thin structure separating the thoracic and abdominal cavities. Numerous pathologic conditions may occur in and around the diaphragm. Due to the shape and complex anatomic relationships of the diaphragm, precise localization, and characterization of these lesions may be at times difficult. The aim of this exhibit is to review the normal diaphragmatic anatomy and its variants, and to illustrate imaging features of a variety of pathologies affect the diaphragm. Various imaging modalities will be presented, including plain radiography, ultrasonography, spiral CT with multiplanar reformation and MR imaging with cine-mode. We will develop the guidelines for imaging choice to do a coherent and efficient work-up.